Tsan, Y.-C., DePalma, S. J., Zhao, Y.-T., Capilnasiu, A., Wu, Y.-W., … O’Leary, T. S., ...Helms, A. S. (2021). Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform. Nature Communications, 12 (1), 6167. [.pdf] [doi]
Rahmanseresht, S., Lee, K. H., O’Leary, T.S., McNamara, J. W., Sadayappan, S., Robbins, J., Warshaw., D. M., Craig, R., & M. J. Previs. (2021). The N Terminus of Myosin-Binding Protein C Extends toward Actin Filaments in Intact Cardiac Muscle. The Journal of General Physiology, 153 (3). [.pdf] [doi]
Lecheta, M.C., Awde, D.N., O'Leary, T.S., Unfried, L.N., Jacobs, N.A., Whitlock, M.H, ... Helms Cahan, S. (2020). Integrating GWAS and transcriptomics to identify the molecular underpinnings of thermal stress responses in Drosophila melanogaster. Frontiers in Genetics, 11 (658), 1–17. [.pdf] [doi]
Daneshparvar, N., Taylor, D.W., O’Leary, T.S., Rahmani, H., Yeganeh, F.A., Previs, M.J., & Taylor, K.A. (2020). CryoEM Structure of Drosophila Flight Muscle Thick Filaments at 7Å Resolution. Life Science Alliance, 3 (8), e202000823. [.pdf] [doi]
Helms, A.S., Tang, V.T., O’Leary, T.S., Friedline S., Wauchope, M., Arora A., … Day S.M. (2020). Effects of MYBPC3 loss of function mutations preceding hypertrophic cardiomyopathy. Journal of Clinical Insights, 5(2) e133782. [.pdf] [doi]
O’Leary, T. S., Snyder, J., Sadayappan, S., Day, S. M., & Previs, M. J. (2019). MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 127, 165–173. [.pdf] [doi]
Li, A., Nelson, S. R., Rahmanseresht, S., Braet, F., Cornachione, A. S., Previs, S., O’Leary, T.S., ... Warshaw, D. M. (2019). Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems. Proceedings of the National Academy of Sciences, 116(43), 21882–21892. [.pdf] [doi]
On the way!
Wood, N. B., O’Leary, T. S., Kelly, C, & Previs, M. J. (submitted for publication). Cardiac muscle thick filaments are maintained by stochastic protein replacement.
Previs, M. J., O’Leary, T. S., Wood, N. B., Morley, M. P., Palmer, B., LeWinter, …, Day, S. M. (submitted for publication). Metabolic and Proteomic Defects in Human Hypertrophic Cardiomyopathy. [bioRxiv]